Abstract
Physostigmine, administered intravenously, reversed postural hypotension induced by hypotensive agents, guanethidine, clonidine and dopamine2-receptor agonists. Postural hypotension, induced by pentobarbital sodium, was also reversed by physostigmine. Neostigmine reversed postural hypotension induced by clonidine following intracerebroventricular, but not intravenous administration. It is proposed that centrally acting cholinomimetic agents may be used to manage postural hypotension resulting from suppression of sympathetic nervous system activity.
MeSH terms
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Anesthetics / pharmacology
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Animals
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Antihypertensive Agents / antagonists & inhibitors*
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Antihypertensive Agents / pharmacology
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Blood Pressure / drug effects
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Clonidine / antagonists & inhibitors
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Clonidine / pharmacology
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Guanethidine / antagonists & inhibitors
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Guanethidine / pharmacology
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Heart Rate / drug effects
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Hypotension, Orthostatic / physiopathology
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Hypotension, Orthostatic / prevention & control*
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Injections, Intravenous
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Injections, Intraventricular
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Male
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Neostigmine / administration & dosage
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Neostigmine / antagonists & inhibitors
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Neostigmine / pharmacology
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Pentobarbital / antagonists & inhibitors
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Pentobarbital / pharmacology
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Physostigmine / administration & dosage
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Physostigmine / pharmacology*
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine / drug effects
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Receptors, Dopamine / physiology
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Stereotaxic Techniques
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Sympathetic Nervous System / drug effects
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Sympathetic Nervous System / physiology
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Synaptic Transmission / drug effects
Substances
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Anesthetics
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Antihypertensive Agents
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Receptors, Dopamine
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Neostigmine
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Physostigmine
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Pentobarbital
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Clonidine
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Guanethidine