The lentivirus regulatory proteins REV and REX are site specific RNA binding proteins

Adv Exp Med Biol. 1991:303:15-22. doi: 10.1007/978-1-4684-6000-1_2.

Abstract

These studies demonstrate that HIV-1 REV and HTLV-1 REX are site specific RNA binding proteins. In addition, the REV protein studies indicate a protein domain essential for biological function that is not involved in RRE binding. Lentiviruses are unique among retroviruses in providing gene products to switch expression from early to late genes. Rather than transcriptional control, this is accomplished by regulating RNA transport. A further understanding of these lentiviral genes may identify means of inhibiting viruses responsible for insidious human disease.

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Gene Products, rev / chemistry
  • Gene Products, rev / metabolism*
  • Gene Products, rex / metabolism*
  • HIV-1 / metabolism
  • Human T-lymphotropic virus 1 / metabolism
  • Lentivirus / metabolism*
  • Molecular Sequence Data
  • RNA-Binding Proteins / metabolism
  • rev Gene Products, Human Immunodeficiency Virus

Substances

  • Gene Products, rev
  • Gene Products, rex
  • RNA-Binding Proteins
  • rev Gene Products, Human Immunodeficiency Virus