Abstract
We sequenced the adhesin-cell wall-anchoring domain of the atlE gene of 49 invasive and commensal Staphylococcus epidermidis strains. We identified 22 alleles, which could be separated into two main groups: group 1 (alleles 1 and 6 to 16, 32/49 strains) and group 2 (alleles 2 to 5 and 17 to 22, 17/49 strains). Allele 1 (the type strain sequence) was by far the most prevalent (21 of 49 strains). Multilocus sequence typing showed a clear relationship between the atlE allele and the sequence type (ST), with the "nosocomial" ST27 clone and closely related STs expressing group 1 alleles.
MeSH terms
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Adhesins, Bacterial / genetics*
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Alleles
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Amino Acid Sequence
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Bacterial Typing Techniques
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Base Sequence
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DNA, Bacterial / genetics
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Genes, Bacterial
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Humans
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Molecular Sequence Data
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N-Acetylmuramoyl-L-alanine Amidase / genetics*
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Phylogeny
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Polymorphism, Genetic
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Sequence Homology, Amino Acid
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Species Specificity
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Staphylococcal Infections / microbiology
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Staphylococcus epidermidis / classification
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Staphylococcus epidermidis / genetics*
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Staphylococcus epidermidis / isolation & purification
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Staphylococcus epidermidis / pathogenicity
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Virulence / genetics
Substances
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Adhesins, Bacterial
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DNA, Bacterial
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N-Acetylmuramoyl-L-alanine Amidase
Associated data
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GENBANK/AJ887965
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GENBANK/AJ887966
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GENBANK/AJ887967
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GENBANK/AJ887968
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GENBANK/AJ887969
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GENBANK/AJ887970
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GENBANK/AJ887971
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GENBANK/AJ887972
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GENBANK/AJ887973
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GENBANK/AJ887974
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GENBANK/AJ887975
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GENBANK/AJ887976
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GENBANK/AJ887977
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GENBANK/AJ887978
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GENBANK/AJ887979
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GENBANK/AJ887980
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GENBANK/AJ887981
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GENBANK/AJ887982
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GENBANK/AJ887983
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GENBANK/AJ887984
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GENBANK/AJ887985
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GENBANK/AJ887986