Abstract
We identified the cytolethal distending toxin V (CDT-V) gene cluster in 19 (4.9%) of 391 enterohemorrhagic Escherichia coli O157:H7. cdt-V+ strains belonged to five phage types (PTs) and were most frequent within PTs 14 and 34. CDT-V was expressed in all but two cdt-V+ strains and was lethal to cultured endothelial cells. Subtyping schemes should include cdt-V as a marker to differentiate E. coli O157:H7 even within the same phage type.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Bacterial Toxins / chemistry
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Bacterial Toxins / genetics*
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Bacterial Toxins / toxicity
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Base Sequence
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Cell Line
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Conserved Sequence
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DNA, Bacterial / genetics
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Diarrhea / microbiology
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Endothelium, Vascular / drug effects
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Escherichia coli Infections / microbiology
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Escherichia coli O157 / chemistry
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Escherichia coli O157 / genetics*
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Escherichia coli O157 / pathogenicity*
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Evolution, Molecular
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Genes, Bacterial
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Hemolytic-Uremic Syndrome / microbiology
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Humans
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Multigene Family
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Virulence / genetics
Substances
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Bacterial Toxins
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DNA, Bacterial
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cytolethal distending toxin