[BMP and osteoclastogenesis]

Midori Nakamura; Nobuyuki Udagawa; Yohei Yamamoto; Hiroshi Nakamura

[BMP and osteoclastogenesis]

Clin Calcium. 2006 May;16(5):809-15.

[Article in Japanese]

Authors

Midori Nakamura¹, Nobuyuki Udagawa, Yohei Yamamoto, Hiroshi Nakamura

Affiliation

¹ Matsumoto Dental University, Department of Biochemistry.

PMID: 16679623

Abstract

Bone morphogenetic protein (BMP)-2 markedly enhanced osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand (RANKL). RANKL expressed by osteoblasts is a requirement for osteoclastogenesis, osteoblasts also play important roles in osteoclastogenesis through offering the critical microenvironment for the action of RANKL.

Publication types

English Abstract
Review

MeSH terms

Animals
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins / physiology*
Bone Resorption / genetics
Carrier Proteins / physiology
Cell Differentiation / genetics*
Humans
Membrane Glycoproteins / physiology
Osteoblasts
Osteoclasts / cytology*
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
Transforming Growth Factor beta / physiology

Substances

BMP2 protein, human
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins
Carrier Proteins
Membrane Glycoproteins
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
TNFRSF11A protein, human
TNFSF11 protein, human
Transforming Growth Factor beta