First report of knockdown mutations in the malaria vector Anopheles gambiae from Cameroon

Josiane Etang; Etienne Fondjo; Fabrice Chandre; Isabelle Morlais; Cecile Brengues; Philippe Nwane; Mouhamadou Chouaibou; Hamadou Ndjemai; Frédéric Simard

First report of knockdown mutations in the malaria vector Anopheles gambiae from Cameroon

Am J Trop Med Hyg. 2006 May;74(5):795-7.

Authors

Josiane Etang¹, Etienne Fondjo, Fabrice Chandre, Isabelle Morlais, Cecile Brengues, Philippe Nwane, Mouhamadou Chouaibou, Hamadou Ndjemai, Frédéric Simard

Affiliation

¹ Organisation de Coordination pour la Lutte contre les Endémies en Afrique Centrale, Yaounde, Cameroon.

PMID: 16687682

Abstract

We report the first finding of the knockdown Leu-Phe and Leu-Ser mutations associated with resistance to pyrethroids and DDT insecticides in the malaria mosquito Anopheles gambiae from Cameroon. The Leu-Phe mutation was found in both the M and S molecular forms of An. gambiae. Importantly, two specimens of the S molecular form were found to carry both mutations in a heterozygous state.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anopheles / drug effects
Anopheles / genetics*
Cameroon / epidemiology
DDT / pharmacology
Humans
Insect Vectors / drug effects
Insect Vectors / genetics*
Insecticide Resistance / genetics
Insecticides / pharmacology*
Malaria / epidemiology
Malaria / transmission*
Mosquito Control
Mutation
Pyrethrins / pharmacology

Substances

Insecticides
Pyrethrins
DDT