The authors describe the results of their series of 260 fine (22G) needle aspiration biopsies (FNAB) of thoracic and abdominal lesions. Diagnostic accuracy, technique, eventual complications are valued. They recommend that this diagnostic procedure is performed with 22G needle and scrupulous technique; the FNAB, if so carried out, is a sure, quick and high accurate tool to characterize uncertain lesions, avoiding explorative surgery.