[Endobronchial stenosis in Wegener's granulomatosis]

Rev Med Interne. 2006 Jun;27(6):453-7. doi: 10.1016/j.revmed.2006.03.004. Epub 2006 Apr 5.
[Article in French]

Abstract

Introduction: Endobronchial stenoses are rare in the course of Wegener's granulomatosis, and they occur even more rarely than subglottic stenoses.

Exegesis: We report seven cases of endobronchial stenoses in the setting of Wegener granulomatosis. Neither the pulmonary symptoms nor the systemic manifestations of vasculitis were specific. However 6/7 patients presented a wheezing or an hemoptysis. Bronchial endoscopy has permitted the diagnosis in all cases. Local evolution was cicatricial and symptomatic stenosis in 3 cases (42,8%).

Conclusion: Thus these lesions must be research in any case of pulmonary abnormality in the course of Wegener's granulomatosis, because they may lead to a pejorative prognosis. Moreover general and local treatment must be given early (at the inflammatory stage). After this stage, the local treatments are difficult and not efficient.

Publication types

  • English Abstract

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Aged
  • Biopsy
  • Bronchi / pathology
  • Bronchial Diseases / diagnosis
  • Bronchial Diseases / etiology*
  • Bronchial Diseases / therapy
  • Bronchoscopy
  • Constriction, Pathologic / diagnosis
  • Constriction, Pathologic / etiology
  • Constriction, Pathologic / therapy
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Granulomatosis with Polyangiitis / complications*
  • Granulomatosis with Polyangiitis / diagnosis
  • Granulomatosis with Polyangiitis / therapy
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Lasers
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Retrospective Studies

Substances

  • Adrenal Cortex Hormones
  • Immunosuppressive Agents