Loss-of-function alleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila

Stephanie Lerach; Weiguo Zhang; Xiaomin Bao; Huai Deng; Jack Girton; Jørgen Johansen; Kristen M Johansen

doi:10.1534/genetics.106.059253

Loss-of-function alleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila

Genetics. 2006 Aug;173(4):2403-6. doi: 10.1534/genetics.106.059253. Epub 2006 May 15.

Authors

Stephanie Lerach¹, Weiguo Zhang, Xiaomin Bao, Huai Deng, Jack Girton, Jørgen Johansen, Kristen M Johansen

Affiliation

¹ Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA.

Abstract

In this article we show that hypomorphic loss-of-function alleles of the JIL-1 histone H3S10 kinase are strong suppressors of position effect variegation (PEV) of the wm4 allele and that lack of JIL-1 activity can counteract the effect of the dominant enhancer Evar2-1 on PEV.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Alleles*
Animals
Drosophila
Drosophila Proteins / genetics*
Genes, Dominant*
Genes, Suppressor*
Protein Serine-Threonine Kinases / genetics*

Substances

Drosophila Proteins
JIL-1 protein, Drosophila
Protein Serine-Threonine Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding