Multiple coding sequences for the genome-linked virus protein (VPg) in dicistroviruses

J Invertebr Pathol. 2006 Jun;92(2):100-4. doi: 10.1016/j.jip.2006.03.003. Epub 2006 May 16.

Abstract

N-terminal Edman sequencing of the genome-linked viral protein (VPg) of Plautia stali intestine virus (PSIV, Dicistroviridae) detected heterologus residues. The VPg sequence determined was found to be triplicated in the nonstructural protein precursor. Multiple VPg-like sequences were also found in 10 of the 12 dicistroviruses with a maximum of six copies in Solenopsis invicta virus-1. We postulate that redundant VPg coding sequences facilitate multiplication of dicistroviruses, because fewer cycle of translation of the nonstructural protein precursor produces larger amounts of VPg proteins in parallel with the increased production of capsid proteins by the intergenic internal ribosome entry site mediated translation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Genome, Viral
  • Heteroptera / virology
  • Insect Viruses / genetics*
  • Molecular Sequence Data
  • RNA Viruses / genetics*
  • Repetitive Sequences, Amino Acid / genetics
  • Repetitive Sequences, Nucleic Acid / genetics*
  • Ribonucleoproteins / genetics*
  • Sequence Homology
  • Viral Nonstructural Proteins / genetics*

Substances

  • Ribonucleoproteins
  • Viral Nonstructural Proteins