First report of a linezolid- and vancomycin-resistant Enterococcus faecium strain in Korea

Hae-Gyung Bae; Heungsup Sung; Mi-Na Kim; Eun-Jung Lee; Sung Koo Lee

doi:10.1080/00365540500372945

First report of a linezolid- and vancomycin-resistant Enterococcus faecium strain in Korea

Scand J Infect Dis. 2006;38(5):383-6. doi: 10.1080/00365540500372945.

Authors

Hae-Gyung Bae¹, Heungsup Sung, Mi-Na Kim, Eun-Jung Lee, Sung Koo Lee

Affiliation

¹ Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea.

PMID: 16709544
DOI: 10.1080/00365540500372945

Abstract

We report the first clinical isolate of linezolid- and vancomycin-resistant Enterococcus faecium (VREF) in Korea. The minimum inhibitory concentration of linezolid was in direct proportion to the number of copies of the G2576U mutation according to sequencing and restriction fragment length polymorphism analysis of the 23S rRNA gene.

Publication types

Case Reports

MeSH terms

Acetamides / pharmacology*
Acetamides / therapeutic use
Adult
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Base Sequence
Dose-Response Relationship, Drug
Drug Resistance, Multiple, Bacterial / genetics
Enterococcus faecium / drug effects*
Enterococcus faecium / genetics
Gram-Positive Bacterial Infections / drug therapy*
Gram-Positive Bacterial Infections / microbiology
Humans
Korea
Linezolid
Male
Microbial Sensitivity Tests
Mutation
Oxazolidinones / pharmacology*
Oxazolidinones / therapeutic use
Polymorphism, Restriction Fragment Length
Treatment Outcome
Vancomycin Resistance* / genetics

Substances

Acetamides
Anti-Bacterial Agents
Oxazolidinones
Linezolid