Abstract
The cytotoxicity of naphthazarin derivatives isolated from the roots of Onosma arenaria on human cervix adenocarcinoma cells (HeLa) and leukaemia K562 cells, as well on non-malignant peripheral blood mononuclear cells (PBMC) was studied. The results show that beta-hydroxyisovalerylalkannin, acetylalkannin and the pigment fraction exhibited high cytotoxicity in vitro against the tested cell lines, as well the healthy PBMC before or after activation with phytohaemagglutinin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / drug therapy
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / toxicity
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Boraginaceae / chemistry*
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Cell Line, Tumor
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Female
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Humans
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Inhibitory Concentration 50
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Leukemia / drug therapy
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Leukocytes, Mononuclear / drug effects
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Naphthoquinones / chemistry*
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Naphthoquinones / pharmacology
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Naphthoquinones / toxicity*
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Phytohemagglutinins / pharmacology
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Phytotherapy
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Plant Roots / chemistry
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Uterine Cervical Neoplasms / drug therapy
Substances
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Antineoplastic Agents, Phytogenic
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Naphthoquinones
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Phytohemagglutinins
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naphthazarin