Abstract
Among 16 human immunodeficiency virus-infected (subtype C) Batswana patients who failed nelfinavir (NFV)-containing regimens, the most prevalent mutation observed was D30N (54%), followed by L90M (31%). L89I, K20T/I, and E35D polymorphic changes were also identified. These findings suggest that subtype C viruses in Botswana may develop resistance to NFV via subtype-specific pathways.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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CD4 Lymphocyte Count
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Drug Resistance, Viral / genetics*
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Genetic Variation
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HIV Infections / drug therapy
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HIV Infections / epidemiology
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HIV Infections / virology*
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HIV Protease Inhibitors / pharmacology*
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HIV Protease Inhibitors / therapeutic use
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HIV-1 / classification
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HIV-1 / drug effects*
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HIV-1 / genetics*
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HIV-1 / isolation & purification
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Humans
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Mutation*
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Nelfinavir / pharmacology*
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Nelfinavir / therapeutic use
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Phylogeny
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Polymorphism, Genetic
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Prevalence
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RNA, Viral / chemistry
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RNA, Viral / genetics
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Selection, Genetic
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Treatment Failure
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Viral Load
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Virus Replication / drug effects
Substances
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HIV Protease Inhibitors
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RNA, Viral
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Nelfinavir