Caspofungin susceptibility in Aspergillus and non-Aspergillus molds: inhibition of glucan synthase and reduction of beta-D-1,3 glucan levels in culture

Antimicrob Agents Chemother. 2006 Jun;50(6):2214-6. doi: 10.1128/AAC.01610-05.

Abstract

Caspofungin inhibits synthesis of beta-D-1,3 glucan, essential to cell walls in Candida and Aspergillus spp., but activity against less common molds is largely uncharacterized. We demonstrate that caspofungin inhibits beta-D-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.

Publication types

  • Comparative Study

MeSH terms

  • Antifungal Agents / pharmacology*
  • Aspergillus fumigatus / drug effects*
  • Aspergillus fumigatus / genetics
  • Aspergillus fumigatus / growth & development
  • Aspergillus fumigatus / isolation & purification
  • Caspofungin
  • Echinocandins
  • Fluorescent Dyes
  • Fungi / drug effects*
  • Fungi / genetics
  • Fungi / growth & development
  • Fungi / isolation & purification
  • Glucosyltransferases / antagonists & inhibitors*
  • In Vitro Techniques
  • Lipopeptides
  • Microbial Sensitivity Tests
  • Peptides, Cyclic / pharmacology*
  • beta-Glucans / metabolism*

Substances

  • Antifungal Agents
  • Echinocandins
  • Fluorescent Dyes
  • Lipopeptides
  • Peptides, Cyclic
  • beta-Glucans
  • Glucosyltransferases
  • glucan synthase
  • Caspofungin