Abstract
The aim of this study was to investigate imipenem distribution in muscle and lung interstitial fluids of rats with Acinetobacter baumannii pulmonary infection. By combining microdialysis in blood and tissues, it was possible to demonstrate that free imipenem concentrations were virtually identical in blood, muscle, and lung.
MeSH terms
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Acinetobacter Infections / drug therapy
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Acinetobacter Infections / microbiology
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Acinetobacter baumannii / drug effects*
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacokinetics*
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Extracellular Fluid / metabolism*
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Imipenem / administration & dosage
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Imipenem / pharmacokinetics*
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Lung / metabolism*
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Male
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Microdialysis / methods*
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Muscle, Skeletal / metabolism*
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Pneumonia, Bacterial / drug therapy
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Pneumonia, Bacterial / microbiology
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Rats
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Rats, Sprague-Dawley
Substances
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Anti-Bacterial Agents
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Imipenem