Interleukin 4 promotes expression of mast cell ICAM-1 antigen

Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3339-42. doi: 10.1073/pnas.88.8.3339.

Abstract

Cell recognition molecules play a crucial role in the regulation of immune cells. We recently found that mast cells (MCs) express leukocyte recognition molecules, including ICAM-1 antigen, a natural ligand of LFA-1. We here report that interleukin 4 (IL-4), a pleiotropic cytokine and mast cell differentiation factor, selectively promotes expression of surface ICAM-1 antigen and ICAM-1 mRNA in human MCs. IL-4 also up-regulates ICAM-1 antigen in cells of monocyte/macrophage lineage but has no effect on ICAM-1 antigen expressed on basophils, fibroblasts, or lymphocytes. The increase in expression of mast cell/macrophage ICAM-1 antigen induced by IL-4 may contribute to the accumulation of leukocytes and facilitate cell-contact-dependent regulation of immune cells in inflamed tissues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / genetics*
  • Antigens, CD / metabolism
  • Blotting, Northern
  • Cell Adhesion Molecules / genetics*
  • Cell Adhesion Molecules / metabolism
  • Cell Division / drug effects
  • Flow Cytometry
  • Gene Expression / drug effects
  • Humans
  • In Vitro Techniques
  • Intercellular Adhesion Molecule-1
  • Interleukin-4 / pharmacology*
  • Leukemia, Mast-Cell
  • Mast Cells / physiology*
  • RNA, Messenger / genetics
  • Receptors, Interleukin-4
  • Receptors, Mitogen / metabolism
  • Tumor Cells, Cultured
  • Up-Regulation

Substances

  • Antigens, CD
  • Cell Adhesion Molecules
  • RNA, Messenger
  • Receptors, Interleukin-4
  • Receptors, Mitogen
  • Intercellular Adhesion Molecule-1
  • Interleukin-4