Hairy cell transformation of a B-cell chronic lymphocytic leukemia: a morphological, cytochemical, phenotypic and molecular study

E Duchayne; G Delsol; E Kuhlein; B Klein; X G Zhang; M Attal; G Cassard; G Laurent

Hairy cell transformation of a B-cell chronic lymphocytic leukemia: a morphological, cytochemical, phenotypic and molecular study

Leukemia. 1991 Feb;5(2):150-5.

Authors

E Duchayne¹, G Delsol, E Kuhlein, B Klein, X G Zhang, M Attal, G Cassard, G Laurent

Affiliation

¹ Laboratoire de Cytologie et Cytogénétique, CRTS, Purpan, Toulouse, France.

PMID: 1673487

Abstract

The normal counterparts of the B cells found in hairy cell leukemia (HCL) are not known. We report here a detailed morphological, cytochemical, immunological and molecular analysis of a patient with B-cell chronic lymphocytic leukemia (B-CLL) who later in the course of his disease developed hairy cell leukemia. We speculate that hairy cell transformation of B-CLL might be related to an in vivo protein kinase C mediated cellular activation of B-CLL cells.

Publication types

Case Reports

MeSH terms

Blotting, Southern
Chromosome Deletion
Chromosomes, Human, Pair 14
Gene Rearrangement
Humans
Immunoglobulin Heavy Chains / genetics
Immunophenotyping
Leukemia, Hairy Cell / pathology*
Leukemia, Lymphocytic, Chronic, B-Cell / complications
Leukemia, Lymphocytic, Chronic, B-Cell / genetics
Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
Male
Middle Aged
Polymorphism, Restriction Fragment Length

Substances

Immunoglobulin Heavy Chains