Abstract
Splenic lymphocytes from (BALB/c times A/J) F 1 mice are cytotoxic for BALB/c fibroblasts infected with an endogenous C-type leukemia virus, but are not cytotoxic for uninfected BALB/c fibroblasts. These results indicate that mice do not exhibit cell-mediated immune tolerance to antigens associated with endogenous C-type viruses.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens, Viral*
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Cell Line
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Cytotoxicity Tests, Immunologic
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Fibroblasts
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Genotype
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Histocompatibility
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Immunity, Cellular*
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Leukemia Virus, Murine / immunology*
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Lymphocytes / immunology
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Male
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Mice
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Mice, Inbred A
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Mice, Inbred BALB C
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Retroviridae / immunology*
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Species Specificity
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Spleen / cytology
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Spleen / immunology