Rethinking the microprocessor

Hervé Seitz; Phillip D Zamore

doi:10.1016/j.cell.2006.05.018

Rethinking the microprocessor

Cell. 2006 Jun 2;125(5):827-9. doi: 10.1016/j.cell.2006.05.018.

Authors

Hervé Seitz¹, Phillip D Zamore

Affiliation

¹ Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01532, USA.

PMID: 16751089
DOI: 10.1016/j.cell.2006.05.018

Abstract

MicroRNAs (miRNAs) are tiny regulators of gene expression that are processed from longer primary transcripts. In this issue, Han et al. (2006) report some of the structural features of the primary transcript that ensure that the Drosha-DGCR8 enzyme complex liberates precisely the correct precursor sequence, enabling production of a fully functional miRNA.

Publication types

Comment
Review

MeSH terms

Animals
Evolution, Molecular
Humans
MicroRNAs / biosynthesis*
MicroRNAs / genetics
Models, Molecular
Nucleotides / genetics
Proteins / genetics
Proteins / metabolism
RNA Precursors / genetics
RNA Precursors / metabolism*
RNA Processing, Post-Transcriptional / genetics
RNA Processing, Post-Transcriptional / physiology*
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism
Ribonuclease III / genetics
Ribonuclease III / metabolism*

Substances

DGCR8 protein, human
MicroRNAs
Nucleotides
Proteins
RNA Precursors
RNA-Binding Proteins
DROSHA protein, human
Ribonuclease III