Dilated cardiomyopathy (DCMP) is a non-coronary heart disease, which leads to the severe degenerative changes and destruction of cardiomyocytes, heart chamber dilatation, systolic and diastolic myocardial dysfunction, steady heart failure progression, disability, and high mortality. HIV is considered to be one of the possible causes of DCMP. Heart involvement in AIDS influences prognosis by lowering survival rate. The number of HIV-infected patients grows in our country; thus, the number of patients with various AIDS manifestations is going to grow, too. In this article the authors adduce the observation of DCMP development in a HIV-infected patient.