A diversity oriented synthesis of 3'-O-modified nucleoside triphosphates for DNA 'sequencing by synthesis'

Genliang Lu; Kevin Burgess

doi:10.1016/j.bmcl.2006.05.035

A diversity oriented synthesis of 3'-O-modified nucleoside triphosphates for DNA 'sequencing by synthesis'

Bioorg Med Chem Lett. 2006 Aug 1;16(15):3902-5. doi: 10.1016/j.bmcl.2006.05.035. Epub 2006 Jun 6.

Authors

Genliang Lu¹, Kevin Burgess

Affiliation

¹ Department of Chemistry, Texas A&M University, PO Box 300012, College Station, TX 77842-3012, USA.

PMID: 16757167
DOI: 10.1016/j.bmcl.2006.05.035

Abstract

The nucleoside triphosphates 1, containing a photochemically cleavable group, and 2, having one that may be cleaved via palladium catalysis, were prepared as a prelude to investigating sequencing of DNA via sequencing by synthesis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Nucleotides / chemical synthesis*
Sequence Analysis, DNA / methods*

Substances

Nucleotides

Abstract

Publication types

MeSH terms

Substances

Grants and funding