A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome

Yong Wang; XiaoKe Wu; Yunxia Cao; Long Yi; Jianxiu Chen

doi:10.1016/j.fertnstert.2005.12.037

A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome

Fertil Steril. 2006 Jul;86(1):223-6. doi: 10.1016/j.fertnstert.2005.12.037. Epub 2006 Jun 9.

Authors

Yong Wang¹, XiaoKe Wu, Yunxia Cao, Long Yi, Jianxiu Chen

Affiliation

¹ Human Genetic Identification Laboratory, Medical School of Nanjing University, Nanjing, China.

PMID: 16764871
DOI: 10.1016/j.fertnstert.2005.12.037

Abstract

A (tttta)n microsatellite polymorphism in the promoter of CYP11a gene was investigated in 201 Chinese Han women with polycystic ovary syndrome (PCOS) and 147 control women. The 6/6 genotype was defined with significant difference of CYP11a polymorphism between women with PCOS and control women, and associated with greater BMI in PCOS patients, suggesting a certain role of the six-repeat allele variant in the pathogenesis of Chinese women with PCOS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Biomarkers, Tumor / genetics
China / epidemiology
Cholesterol Side-Chain Cleavage Enzyme / genetics*
DNA Mutational Analysis / methods
Female
Genetic Predisposition to Disease / epidemiology
Genetic Predisposition to Disease / genetics
Genetic Testing / methods*
Humans
Incidence
Microsatellite Repeats / genetics
Polycystic Ovary Syndrome / enzymology*
Polycystic Ovary Syndrome / epidemiology*
Polycystic Ovary Syndrome / genetics
Polymorphism, Genetic
Risk Assessment / methods*
Risk Factors

Substances

Biomarkers, Tumor
Cholesterol Side-Chain Cleavage Enzyme