Abstract
Drug resistance eventually limits the effectiveness of antiestrogens in breast cancer treatment. Pharmacological reversal of this refractoriness has been attempted with R-Verapamil, a well tolerated calcium channel blocker. This drug significantly decreased the incidence of lung foci after intravenous seeding of the R3230AC rat adenocarcinoma; this effect was correlated with reduction in the expression of P-glycoprotein. The simultaneous administration of antiestrogens with a non-toxic enantiomer of Verapamil was beneficial in the tumour model investigated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Adenocarcinoma / drug therapy*
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Adenocarcinoma / pathology
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Animals
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Drug Resistance
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Female
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Isomerism
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Liver / drug effects
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Liver / enzymology
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Liver / pathology
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Liver Function Tests
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Lung Neoplasms / prevention & control
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Lung Neoplasms / secondary*
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Mammary Neoplasms, Experimental / drug therapy*
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Mammary Neoplasms, Experimental / pathology
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Membrane Glycoproteins / analysis*
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Rats
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Rats, Inbred F344
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Tamoxifen / therapeutic use*
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Verapamil / therapeutic use*
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Verapamil / toxicity
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Membrane Glycoproteins
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Tamoxifen
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Verapamil