Abstract
Adenosine 5' monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. It mediates some of the effects of peripheral hormones such as leptin, ghrelin and adiponectin, and it is involved in the insulin-sensitizing role of the antidiabetic drug metformin. There is increasing evidence that AMPK has a central role in mediating the appetite-modulating and metabolic effects of many other hormones and substances, including the cannabinoids. Recent studies have illustrated the interaction between hormones and AMPK, and highlighted AMPK as a potential target for the development of tissue-specific AMPK modulators in the treatment of obesity and the metabolic syndrome.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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AMP-Activated Protein Kinases
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Adiponectin / physiology
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Animals
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Appetite Regulation / physiology
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Cannabinoids / biosynthesis
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Cannabinoids / pharmacology
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Cytokines / metabolism
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Endocrine System / physiology*
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Fatty Acid Synthases / physiology
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Ghrelin
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Glucose / metabolism
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Glucose / pharmacology
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Humans
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Hypothalamic Hormones / physiology
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Insulin / pharmacology
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Leptin / physiology
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Metformin / pharmacology
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Models, Biological
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Multienzyme Complexes / physiology*
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Peptide Hormones / physiology
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Protein Serine-Threonine Kinases / physiology*
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Receptors, Adrenergic / metabolism
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Resistin / physiology
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Rosiglitazone
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Thiazolidinediones / pharmacology
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Thioctic Acid / physiology
Substances
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Adiponectin
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Cannabinoids
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Cytokines
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Ghrelin
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Hypothalamic Hormones
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Insulin
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Leptin
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Multienzyme Complexes
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Peptide Hormones
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Receptors, Adrenergic
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Resistin
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Thiazolidinediones
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Rosiglitazone
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Thioctic Acid
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Metformin
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Fatty Acid Synthases
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Protein Serine-Threonine Kinases
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AMP-Activated Protein Kinases
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Glucose