Abstract
The Hedgehog pathway was recently shown to antagonise constitutive activity of the Wnt pathway that drives proliferation of colorectal cancer cells. Studies in this issue of Gut refine our understanding of the underlying mechanism and provide evidence for such antagonism in colorectal cancers in vivo
MeSH terms
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Carrier Proteins / metabolism*
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Cell Proliferation
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Colorectal Neoplasms / metabolism*
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Colorectal Neoplasms / pathology
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Humans
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Intestinal Mucosa / pathology
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Membrane Glycoproteins / metabolism*
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Signal Transduction / physiology*
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Wnt Proteins / metabolism*
Substances
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Carrier Proteins
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HHIP protein, human
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Membrane Glycoproteins
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Wnt Proteins