Visceral obesity and insulin resistance are typical clinical features of nonalcoholic steatohepatitis (NASH) characterized by zone 3-dominant hepatic steatosis with ballooned hepatocytes and Mallory bodies, zone 3 pericellular and perivenular fibrosis with or without bridging fibrosis, and lobular inflammatory cell infiltration. Indeed, 90% of NASH revealed to be complicated with visceral obesity, and two thirds of NASH patients fulfill the criteria of metabolic syndrome. Therefore, NASH could be regarded as the hepatic manifestation of metabolic syndrome, and a variety of life-style related diseases such as obesity, hypertension, hyperlipidemia and diabetes mellitus could be used for detecting