Headache is the most frequent pain disorder, and 31% of the adult Danish population has sought medical assistance due to headache. In addition, the socio-economic costs of headache are substantial, and a national treatment strategy is therefore important. With respect to treatment of migraine, considerable scientific progress has been made, whereas the scientific interest in and treatment of the highly prevalent tension-type headache are insufficient. The most frequent primary headache disorders, their differential diagnosis and the current treatment strategy are briefly reviewed.