Inguinal and iliac lymph node involvement in germ cell tumours of the testis: implications for radiological investigation and for therapy

Clin Oncol (R Coll Radiol). 1991 May;3(3):147-50. doi: 10.1016/s0936-6555(05)80835-0.

Abstract

The clinical details of 1191 patients with primary germ cell tumours of the testis seen at the Royal Marsden Hospital between 1977 and 1989 were reviewed in order to determine the incidence of inguinal or iliac node metastases. This was detected in 22 patients, 11 with inguinal and 11 with iliac lymphadenopathy. Seven of these patients had a history of maldescent and orchidopexy, and one patient had congenitally fused testes. Of the remaining 14 patients, eight had bulky para-aortic lymphadenopathy (5 cm or greater in diameter), one had histological evidence of breach of the tunica vaginalis by tumour, and in five patients no predisposing factors were identified. Eight patients had a seminoma, 11 a non-seminoma, and two a combined tumour. Inguinal or iliac nodes were significantly more common in the group of patients defined by bulky para-aortic disease or a history of maldescent and orchidopexy (15/267) than those without either factor (7/924, P less than 0.0004). Patients with a history of maldescent, congenital anomalies of the genitourinary system, or with bulky para-aortic disease, should routinely have the pelvis and inguinal regions included in a staging or follow-up CT scan. These factors should also influence the extent of the radiation field or of surgical dissection when these modalities are employed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cryptorchidism / pathology
  • Dysgerminoma / diagnostic imaging
  • Dysgerminoma / pathology
  • Dysgerminoma / secondary
  • Humans
  • Ilium
  • Inguinal Canal
  • Lymphatic Metastasis* / diagnostic imaging
  • Lymphatic Metastasis* / pathology
  • Male
  • Neoplasm Staging
  • Neoplasms, Germ Cell and Embryonal / diagnostic imaging
  • Neoplasms, Germ Cell and Embryonal / pathology
  • Neoplasms, Germ Cell and Embryonal / secondary*
  • Para-Aortic Bodies / pathology
  • Risk Factors
  • Testicular Neoplasms / diagnostic imaging
  • Testicular Neoplasms / pathology*
  • Testis / surgery
  • Tomography, X-Ray Computed