Abstract
The prognosis of stage IV malignant rhabdoid tumor of the kidney (MRTK) has been extremely poor. However, a combination of ICE (ifosfamide, carboplatin, and etoposide) and VDCy (vincristine, doxorubicin, and cyclophosphamide) was recently reported to be effective for metastatic MRTK. We describe a 21-month-old girl with stage IV MRTK who was successfully treated with ICE, VDCy, and radiotherapy. She remained well, without recurrence, 24 months after diagnosis. Alternating therapy with ICE and VDCy might become a standard regimen for stage IV MRTK, although further study is required to confirm its effectiveness.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
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Cisplatin / administration & dosage
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Etoposide / administration & dosage
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Female
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Humans
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Ifosfamide / administration & dosage
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Infant
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Kidney Neoplasms / drug therapy*
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Kidney Neoplasms / pathology
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Kidney Neoplasms / radiotherapy
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Remission Induction / methods
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Rhabdoid Tumor / drug therapy*
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Rhabdoid Tumor / pathology
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Rhabdoid Tumor / radiotherapy
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Vincristine / administration & dosage
Substances
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Vincristine
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Etoposide
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Doxorubicin
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Cyclophosphamide
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Cisplatin
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Ifosfamide