Abstract
Mononuclear cells (MNC) in synovial fluids from patients with rheumatoid arthritis and other arthropathies differ clearly from MNC in peripheral blood. Typically the ratio of CD4(+)-/CD8+ lymphocytes is inverted and the response to mitogens/cytokines (IL-1/IL-2) is impaired. Active TGF-beta (transforming growth factor beta) was found to account for these abnormalities, and the major isoform was identified as TGF-beta 2.
MeSH terms
-
Arthritis, Rheumatoid / immunology*
-
CD4-Positive T-Lymphocytes / immunology
-
Cells, Cultured
-
Humans
-
Immunity, Cellular
-
Leukocytes, Mononuclear / immunology*
-
Lymphocyte Activation
-
Synovial Fluid / cytology*
-
T-Lymphocytes / immunology*
-
T-Lymphocytes, Helper-Inducer / immunology
-
T-Lymphocytes, Regulatory / immunology
-
Transforming Growth Factor beta / physiology*
Substances
-
Transforming Growth Factor beta