Osteonecrosis of the hip after short courses of oral and inhaled steroids in a child with an increased number of glucocorticoid receptors

Ilenia Drigo; Alessia Saccari; Egidio Barbi; Fiora Bartoli; Giuliana Decorti; Alessandro Ventura

doi:10.1007/s00431-006-0197-x

Osteonecrosis of the hip after short courses of oral and inhaled steroids in a child with an increased number of glucocorticoid receptors

Eur J Pediatr. 2006 Dec;165(12):913-5. doi: 10.1007/s00431-006-0197-x. Epub 2006 Jun 17.

Authors

Ilenia Drigo¹, Alessia Saccari, Egidio Barbi, Fiora Bartoli, Giuliana Decorti, Alessandro Ventura

Affiliation

¹ Department of Reproductive and Developmental Science and IRCCS, Istituto per I'Infanzia Burlo Garofolo, Clinica Pediatrica, Trieste, Italy.

PMID: 16783583
DOI: 10.1007/s00431-006-0197-x

Abstract

We report an unusual case of osteonecrosis of the femoral head associated with recurrent myopathy and bone abnormalities in a two-year-old girl, in whom symptoms occurred after a ten-day course of oral betamethasone for infectious wheezy bronchitis, and eventually recurred and were worsened by topical treatment; a hypersensitivity to glucocorticoids is hypothesised.

Publication types

Case Reports

MeSH terms

Betamethasone / administration & dosage
Betamethasone / adverse effects*
Bronchitis / drug therapy
Child, Preschool
Drug Hypersensitivity / diagnosis
Female
Femur Head Necrosis / chemically induced*
Glucocorticoids / administration & dosage
Glucocorticoids / adverse effects*
Humans
Receptors, Glucocorticoid / metabolism*

Substances

Glucocorticoids
Receptors, Glucocorticoid
Betamethasone