Abstract
Synthesis of C(12) des-methyl ketolide is developed featuring an intramolecular epoxide formation/elimination process to establish the C(12) stereocenter. These ketolides are potent against several key respiratory pathogens, including erythromycin resistant erm- and mef-containing strains of Streptococcus pneumoniae.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Carbon / chemistry*
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Gram-Positive Cocci / drug effects
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Haemophilus influenzae / drug effects
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Ketolides / chemical synthesis
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Ketolides / chemistry*
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Ketolides / pharmacology*
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Methylation
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Molecular Structure
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Ketolides
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Carbon