Abstract
We measured the helical repeats of a non-natural nucleic acid, locked nucleic acid (LNA), by incorporating LNA strands into the outer arms of a DNA double crossover (DX) molecule; atomic force microscopy (AFM) imaging of the two-dimensional (2D) arrays self-assembled from these DX molecules allows us to derive the helical repeat of the LNA/DNA hetero-duplex to be 13.2 +/- 0.9 base pairs per turn.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Base Sequence
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DNA / chemistry*
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DNA / ultrastructure*
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Microscopy, Atomic Force
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Molecular Sequence Data
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Nucleic Acid Denaturation
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Nucleic Acid Hybridization
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Oligonucleotide Array Sequence Analysis
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Oligonucleotides
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Oligonucleotides, Antisense / chemistry*
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Oligonucleotides, Antisense / ultrastructure*
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Temperature
Substances
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Oligonucleotides
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Oligonucleotides, Antisense
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locked nucleic acid
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DNA