Radical-polar crossover domino reactions involving organozinc and mixed organocopper/organozinc reagents

Chemistry. 2006 Aug 25;12(25):6506-13. doi: 10.1002/chem.200600334.

Abstract

A domino process involving Michael addition and carbocyclization has been developed starting from beta-N-allylamino enoates and various organometallic reagents (organozinc halides, diorganozinc reagents, and copper/zinc mixed species). In all cases the mechanism of this domino reaction has been evidenced to involve a radical-polar crossover mechanism.