Synthesis and anti-inflammatory activity of some selected aminothiophene analogs

Khalid Mohammed Khan; Zia Ullah; Muhammad Arif Lodhi; Saima Jalil; Muhammad Iqbal Choudhary; Atta-Ur-Rahman

doi:10.1080/14756360500480418

Synthesis and anti-inflammatory activity of some selected aminothiophene analogs

J Enzyme Inhib Med Chem. 2006 Apr;21(2):139-43. doi: 10.1080/14756360500480418.

Authors

Khalid Mohammed Khan¹, Zia Ullah, Muhammad Arif Lodhi, Saima Jalil, Muhammad Iqbal Choudhary, Atta-Ur-Rahman

Affiliation

¹ International Centerfor Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan. [email protected]

PMID: 16789427
DOI: 10.1080/14756360500480418

Abstract

Some 2-aminothiophene analogs 1-6 were synthesized and characterized. Among the tested compounds, compound 1 (IC50 121.47 microM) exhibited highest while the compound 5 showed least anti-inflammatory potential (IC50 422 microM).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Drug Design
Humans
Inhibitory Concentration 50
Neutrophils / drug effects
Neutrophils / metabolism
Thiophenes / chemical synthesis*
Thiophenes / chemistry
Thiophenes / pharmacology*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Thiophenes