Abstract
An antiapoptotic polymeric nanomedicine, PGA-peptoid 1, has been developed by the conjugation of a novel apoptotic protease activating factor 1 (Apaf-1) inhibitor (peptoid 1) to poly-L-glutamic acid (PGA). Full structural and biophysical characterization of the conjugate by different techniques has been accomplished. This macromolecule clearly enhances the antiapoptotic activity of peptoid 1 in different cell models.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis / drug effects*
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Apoptotic Protease-Activating Factor 1
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Cell Line, Tumor
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Depression, Chemical
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Fibroblasts / cytology
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Fibroblasts / drug effects
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Humans
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In Vitro Techniques
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Intracellular Signaling Peptides and Proteins / antagonists & inhibitors*
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Mice
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Nanotechnology
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Peptoids / chemical synthesis*
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Peptoids / chemistry
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Peptoids / pharmacology
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Polyglutamic Acid / chemistry*
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Proteins / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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APAF1 protein, human
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Apaf1 protein, mouse
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Apoptotic Protease-Activating Factor 1
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Intracellular Signaling Peptides and Proteins
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Peptoids
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Proteins
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Polyglutamic Acid