Effect of endometrioma cystectomy on IVF outcome: a prospective randomized study

Reprod Biomed Online. 2006 May;12(5):639-43. doi: 10.1016/s1472-6483(10)61192-3.

Abstract

The study was conducted to investigate the effect of conservative surgery of ovarian endometriomas before an ICSI cycle. Ninety-nine patients with endometriomas who were referred to an intracytoplasmic sperm injection (ICSI) cycle were enrolled in the study. The patients were prospectively randomized into two groups; group I (49 patients) underwent conservative ovarian surgery before the ICSI cycle and group II (50 patients) underwent the ICSI cycle directly. The stimulation was started 3 months after the operation in group I and directly in group II. In the ovarian surgery group, stimulation was significantly longer (14.0 days in group I and 10.8 days in group II; P = 0.001), total recombinant FSH dose was significantly higher (4575 IU in group I and 3675 IU in group II; P = 0.001), and mean number of mature oocytes was significantly lower (7.8 in group I and 8.6 in group II; P = 0.032). There was no difference in terms of fertilization (86% in group I and 88% in group II), implantation (16.5% in group I and 18.5% in group II) and pregnancy rates (34% in group I and 38% in group II). Ovarian surgery resulted in longer stimulation, higher FSH requirement and lower oocyte number, but fertilization, pregnancy and implantation rates did not differ between the groups.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Embryo Implantation
  • Endometriosis / surgery*
  • Female
  • Fertilization in Vitro / methods*
  • Gynecologic Surgical Procedures / methods*
  • Humans
  • Oocytes / physiology
  • Ovarian Diseases / surgery*
  • Ovulation Induction / methods
  • Pregnancy
  • Pregnancy Rate
  • Prospective Studies
  • Sperm Injections, Intracytoplasmic / methods