Autologous transplantation of CD133+ BM-derived stem cells as a therapeutic option for dilatative cardiomyopathy

Cytotherapy. 2006;8(3):308-10. doi: 10.1080/14653240600735909.

Abstract

We report the case of a 58-year-old man with end-stage non-ischemic cardiomyopathy. Baseline transthoracic echocardiography (TTE) and cardiac magnetic resonance (cMRI) revealed a markedly depressed left ventricle systolic function. He underwent autologous CD133+ BM-derived cell transplantation through a minimally invasive approach. During surgery 19 x 10(6) BM-derived stem cells were injected by the transepimyocardial route. Six months after the operation TTE and cMRI showed a clear improvement in left ventricular contractility.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • AC133 Antigen
  • Antigens, CD / analysis*
  • Bone Marrow Cells / chemistry
  • Bone Marrow Cells / cytology
  • Bone Marrow Transplantation / methods*
  • Cardiomyopathy, Dilated / pathology
  • Cardiomyopathy, Dilated / physiopathology
  • Cardiomyopathy, Dilated / surgery*
  • Echocardiography
  • Glycoproteins / analysis*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Peptides / analysis*
  • Stem Cells / chemistry
  • Stem Cells / cytology*
  • Stroke Volume / physiology
  • Transplantation, Autologous
  • Treatment Outcome

Substances

  • AC133 Antigen
  • Antigens, CD
  • Glycoproteins
  • PROM1 protein, human
  • Peptides