Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures

Antimicrob Agents Chemother. 2006 Jul;50(7):2525-9. doi: 10.1128/AAC.01489-05.

Abstract

The potencies of several alkoxyalkyl esters of acyclic nucleoside phosphonates against vaccinia virus and cowpox virus were evaluated in cell monolayers and three-dimensional epithelial raft cultures. Prodrugs were at least 20-fold more active than their parent compounds. Octadecycloxyethyl-(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine emerged as the most potent derivative.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / pharmacology
  • Antiviral Agents / pharmacology*
  • Cells, Cultured
  • Cidofovir
  • Cyclization
  • Cytopathogenic Effect, Viral
  • Cytosine / analogs & derivatives*
  • Cytosine / chemistry
  • Cytosine / pharmacology
  • Esters
  • Fibroblasts / virology*
  • Humans
  • Keratinocytes / virology*
  • Organophosphonates / chemistry*
  • Organophosphonates / pharmacology*
  • Orthopoxvirus / drug effects*

Substances

  • Antiviral Agents
  • Esters
  • Organophosphonates
  • Cytosine
  • 9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
  • Adenine
  • Cidofovir