Abstract
To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. (11)C-PIB((11)C-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional (11)C-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Alzheimer Disease / diagnostic imaging*
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Alzheimer Disease / metabolism
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Alzheimer Disease / pathology*
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Amyloid / metabolism
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Aniline Compounds
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Atrophy
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Brain / diagnostic imaging
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Brain / metabolism
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Brain / pathology
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Carbon Radioisotopes
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Cohort Studies
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Female
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Humans
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Magnetic Resonance Imaging*
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Male
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Middle Aged
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Positron-Emission Tomography / methods*
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Thiazoles
Substances
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2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
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Amyloid
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Aniline Compounds
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Carbon Radioisotopes
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Thiazoles