Abstract
CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-alpha and IL-1beta. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adipokines / chemistry
-
Adipokines / genetics
-
Adipokines / metabolism*
-
Adipose Tissue / cytology
-
Adipose Tissue / drug effects*
-
Adipose Tissue / metabolism
-
Amino Acid Sequence
-
Animals
-
Cell Differentiation
-
Cloning, Molecular
-
DNA, Complementary / genetics
-
Gene Expression Profiling
-
Gene Expression Regulation / drug effects*
-
Humans
-
Interleukin-1 / pharmacology*
-
Lipopolysaccharides / pharmacology
-
Male
-
Mice
-
Molecular Sequence Data
-
Obesity
-
Proteins / chemistry
-
Proteins / genetics
-
Proteins / metabolism*
-
RNA, Messenger / genetics
-
RNA, Messenger / metabolism
-
Rats
-
Rats, Sprague-Dawley
-
Rats, Zucker
-
Sequence Alignment
-
Tumor Necrosis Factor-alpha / pharmacology*
Substances
-
Adipokines
-
C1QTNF1 protein, human
-
C1qtnf1 protein, rat
-
CTRP1 protein, mouse
-
DNA, Complementary
-
Interleukin-1
-
Lipopolysaccharides
-
Proteins
-
RNA, Messenger
-
Tumor Necrosis Factor-alpha