Mechanistic insight into how Shh patterns the vertebrate limb

Curr Opin Genet Dev. 2006 Aug;16(4):426-32. doi: 10.1016/j.gde.2006.06.013. Epub 2006 Jun 23.

Abstract

The hands and feet of a newborn baby are a beautiful reminder of the complexity of embryonic patterning. Classical studies on how these structures form have led to a theoretical framework for understanding, in general, how discrete groups of cells can instruct differential fates across a wider field through the action of long-range signals. The discovery just more than a decade ago that localized expression of Sonic hedgehog (Shh) differentially patterns structures across the limb field, resulting in digits with unique characteristics, provided a starting point for readdressing these models at a molecular level. Current research has revealed unexpected complexity in how a gradient of Shh activity is both established and received, prompting re-evaluation of the nature of patterning mechanisms within the limb.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Body Patterning*
  • Cell Movement
  • Cell Proliferation
  • Extremities / embryology*
  • Hedgehog Proteins
  • Humans
  • Limb Buds / cytology
  • Limb Buds / embryology
  • Signal Transduction
  • Trans-Activators / physiology*
  • Vertebrates / embryology*

Substances

  • Hedgehog Proteins
  • SHH protein, human
  • Trans-Activators