Abstract
In the present study, a local inflammatory response in white adipose tissue from the nonobese HSL-null mouse model is demonstrated. The protein levels of several well-known markers of inflammation, like TNFalpha and ferritin HC, were highly increased and accompanied by an activation of NFkappaB. A number of macrophage proteins, i.e., gal-3, Capg, and MCP-4, were expressed at increased levels and immunohistochemical analyses revealed an increased infiltration of F4/80+ cells.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipose Tissue / enzymology*
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Adipose Tissue / pathology
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Animals
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Crosses, Genetic
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Diet
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Dietary Fats / administration & dosage
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Female
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Galactosephosphates / metabolism
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Immunohistochemistry
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Inflammation
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Mice
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Mice, Inbred C57BL
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Mice, Inbred Strains
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Mice, Knockout
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Microfilament Proteins / metabolism
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Models, Biological
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NF-kappa B / metabolism
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Nuclear Proteins / metabolism
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Peptide Mapping
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Proteome / analysis*
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Proteomics
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Serine Endopeptidases / analysis
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Sterol Esterase / genetics
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Sterol Esterase / physiology*
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Dietary Fats
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Galactosephosphates
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Microfilament Proteins
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NF-kappa B
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Nuclear Proteins
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Proteome
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Tumor Necrosis Factor-alpha
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galactitol 3-phosphate
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Capg protein, mouse
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Sterol Esterase
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Serine Endopeptidases
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mast cell protease 4