Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques

Y J Rosenberg; B D White; S F Papermaster; P Zack; P B Jarling; G A Eddy; D S Burke; M G Lewis

Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques

J Med Primatol. 1991 Jun;20(4):206-10.

Authors

Y J Rosenberg¹, B D White, S F Papermaster, P Zack, P B Jarling, G A Eddy, D S Burke, M G Lewis

Affiliation

¹ Henry M. Jackson Foundation Research Laboratory, Rockville, MD 20850.

PMID: 1682498

Abstract

In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate, only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) and "activated" (CD45RAhi) T-cell subsets, it was seen that PBMC from pig-tailed and cynomolgus monkeys, unlike rhesus, have reduced CD4/CD8 ratios and a skewing of T cells towards CD45RAhi expression. Such preactivation of CD4+ cells could lead to enhanced viral replication and early death.

MeSH terms

Acute Disease
Animals
Antigens, CD / biosynthesis
CD4-Positive T-Lymphocytes / immunology
Disease Susceptibility
Histocompatibility Antigens / biosynthesis
Leukocyte Common Antigens
Lymphocyte Activation
Macaca fascicularis
Macaca mulatta
Macaca nemestrina
Macaca*
Phenotype
Simian Acquired Immunodeficiency Syndrome / immunology*
Simian Acquired Immunodeficiency Syndrome / mortality
Simian Immunodeficiency Virus / immunology*
T-Lymphocytes / immunology*
T-Lymphocytes, Regulatory / immunology

Substances

Antigens, CD
Histocompatibility Antigens
Leukocyte Common Antigens