Abstract
The applicability of a multilocus sequence analysis (MLSA)-based identification system for lactobacilli was evaluated. Two housekeeping genes that code for the phenylalanyl-tRNA synthase alpha-subunit (pheS) and RNA polymerase alpha-subunit (rpoA) were sequenced and analysed for members of the Lactobacillus salivarius species group. The type strains of Lactobacillus acidipiscis and Lactobacillus cypricasei were investigated further using a third gene that encodes the alpha-subunit of ATP synthase (atpA). The MLSA data revealed close relatedness between L. acidipiscis and L. cypricasei, with 99.8-100 % pheS, rpoA and atpA gene sequence similarities. Comparison of the 16S rRNA gene sequences of the type strains of the two species confirmed the close relatedness (99.8 % gene sequence similarity) between the two taxa. Similar phenotypes and high DNA-DNA binding values in the range of 84 to 97.5 % confirmed that L. acidipiscis and L. cypricasei are synonymous species. On the basis of the present study, it is proposed that Lactobacillus cypricasei is a later heterotypic synonym of Lactobacillus acidipiscis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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DNA-Directed RNA Polymerases / genetics
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Lactobacillus / classification*
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Lactobacillus / genetics
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Mitochondrial Proton-Translocating ATPases / genetics
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Molecular Sequence Data
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Nucleic Acid Hybridization
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Phenylalanine-tRNA Ligase / genetics
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Phylogeny
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Protein Subunits / genetics
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RNA, Ribosomal, 16S / genetics
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Sequence Analysis, DNA
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Sequence Homology, Nucleic Acid
Substances
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Bacterial Proteins
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DNA, Bacterial
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Protein Subunits
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RNA, Ribosomal, 16S
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DNA-Directed RNA Polymerases
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RNA polymerase alpha subunit
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Mitochondrial Proton-Translocating ATPases
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Phenylalanine-tRNA Ligase
Associated data
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GENBANK/AM087679
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GENBANK/AM087687
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GENBANK/AM087708
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GENBANK/AM087717
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GENBANK/AM087721
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GENBANK/AM087734
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GENBANK/AM087737
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GENBANK/AM087740
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GENBANK/AM087746
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GENBANK/AM087756
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GENBANK/AM087760
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GENBANK/AM087762
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GENBANK/AM087784
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GENBANK/AM087801
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GENBANK/AM087831
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GENBANK/AM087849
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GENBANK/AM168423
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GENBANK/AM168424
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GENBANK/AM168425
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GENBANK/AM168426
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GENBANK/AM168427
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GENBANK/AM168428
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GENBANK/AM168429
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GENBANK/AM168431
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GENBANK/AM168432
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GENBANK/AM168433