Factors associated with immunoglobulin G subclass polarization in naturally acquired antibodies to Plasmodium falciparum merozoite surface proteins: a cross-sectional survey in Brazilian Amazonia

Kézia K G Scopel; Cor J F Fontes; Marcelo U Ferreira; Erika M Braga

doi:10.1128/CVI.00095-06

Factors associated with immunoglobulin G subclass polarization in naturally acquired antibodies to Plasmodium falciparum merozoite surface proteins: a cross-sectional survey in Brazilian Amazonia

Clin Vaccine Immunol. 2006 Jul;13(7):810-3. doi: 10.1128/CVI.00095-06.

Authors

Kézia K G Scopel¹, Cor J F Fontes, Marcelo U Ferreira, Erika M Braga

Affiliation

¹ Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 31270-901 Belo Horizonte (MG), Brazil.

Abstract

We investigated immunoglobulin G (IgG) subclass antibody responses to Plasmodium falciparum merozoite surface protein 1 (MSP-1) and MSP-2 in 112 malaria-exposed subjects in Brazil. IgG3 polarization was primarily epitope driven, being little affected by cumulative or current exposure to malaria and not affected by a subject's age and Fcgamma receptor IIA genotype.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Animals
Antibodies, Protozoan / blood
Antibodies, Protozoan / classification
Antigens, Protozoan / immunology*
Cross-Sectional Studies
Female
Humans
Immunoglobulin G / blood*
Immunoglobulin G / classification*
Malaria, Falciparum / immunology
Malaria, Falciparum / parasitology
Male
Merozoite Surface Protein 1 / immunology*
Middle Aged
Plasmodium falciparum / immunology*

Substances

Antibodies, Protozoan
Antigens, Protozoan
Immunoglobulin G
Merozoite Surface Protein 1