Selective recognition of pyrophosphate in water using a backbone modified cyclic peptide receptor

Chem Commun (Camb). 2006 Jul 28:(28):2971-3. doi: 10.1039/b606917g. Epub 2006 Jun 22.

Abstract

A cyclic peptide based receptor, bearing two dipicolylamino arms complexed to zinc(II) ions, binds pyrophosphate ions with high affinity and selectivity in aqueous solution as determined using an indicator displacement assay.

MeSH terms

  • Diphosphates / chemistry*
  • Diphosphates / metabolism
  • Models, Molecular
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / metabolism
  • Receptors, Peptide / chemistry*
  • Receptors, Peptide / metabolism
  • Water / chemistry*
  • Water / metabolism
  • Zinc / chemistry
  • Zinc / metabolism

Substances

  • Diphosphates
  • Peptides, Cyclic
  • Receptors, Peptide
  • Water
  • Zinc