A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions

Bruce Z Lu; Wenyi Zhao; Han-Xun Wei; Marine Dufour; Vittorio Farina; Chris H Senanayake

doi:10.1021/ol061136q

A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions

Org Lett. 2006 Jul 20;8(15):3271-4. doi: 10.1021/ol061136q.

Authors

Bruce Z Lu¹, Wenyi Zhao, Han-Xun Wei, Marine Dufour, Vittorio Farina, Chris H Senanayake

Affiliation

¹ Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc., Suite 205, East Leigh Street, Richmond, Virginia 23219, USA. [email protected]

PMID: 16836383
DOI: 10.1021/ol061136q

Abstract

[Structure: see text] A practical one-pot, regiospecific three-component process for the synthesis of 2,3-disubstituted indoles was developed via consecutive Pd-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.

MeSH terms

Catalysis
Combinatorial Chemistry Techniques*
Indoles / chemical synthesis*
Molecular Structure
Palladium / chemistry

Substances

Indoles
Palladium