The role of CD44 adhesion molecule in oral cavity cancer

A Georgolios; A Batistatou; A Charalabopoulos; L Manolopoulos; K Charalabopoulos

The role of CD44 adhesion molecule in oral cavity cancer

Exp Oncol. 2006 Jun;28(2):94-8.

Authors

A Georgolios¹, A Batistatou, A Charalabopoulos, L Manolopoulos, K Charalabopoulos

Affiliation

¹ Department of Physiology, Division of Adhesion Molecules, Ioannina University Medical School, Ioannina, Greece. [email protected]

PMID: 16837897

Abstract

CD44 is an adhesion molecule, member of the transmembrane glucoprotein family, with large number of isoforms identified in many human tissues, with particularly high expression in proliferating cells and squamous cell epithelium. This review is focused on the role of CD44 in the carcinogenesis of the oral cavity with special emphasis on its potential use for diagnosis and prognosis of cancer of oral cavity.

Publication types

Review

MeSH terms

Biomarkers, Tumor / analysis*
Biomarkers, Tumor / metabolism
Carcinoma, Squamous Cell / diagnosis*
Carcinoma, Squamous Cell / etiology*
Carcinoma, Squamous Cell / metabolism
Humans
Hyaluronan Receptors / analysis*
Hyaluronan Receptors / metabolism
Hyaluronan Receptors / physiology*
Mouth Neoplasms / diagnosis*
Mouth Neoplasms / etiology*
Mouth Neoplasms / metabolism
Prognosis

Substances

Biomarkers, Tumor
Hyaluronan Receptors