Abstract
The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 'spike' structure determined by single-particle cryo-EM, along with the docked atomic structures of the receptor-binding domain and prefusion core.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chlorocebus aethiops
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Cryopreservation / methods
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Epitopes / chemistry
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Image Processing, Computer-Assisted
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Membrane Fusion / physiology
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Microscopy, Electron / methods
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Models, Molecular
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Severe acute respiratory syndrome-related coronavirus / chemistry
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Severe acute respiratory syndrome-related coronavirus / pathogenicity
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Severe acute respiratory syndrome-related coronavirus / ultrastructure*
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Vero Cells / virology
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Viral Envelope Proteins / chemistry*
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Viral Envelope Proteins / metabolism
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Virion / chemistry
Substances
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Epitopes
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Viral Envelope Proteins